Alprostadil injections, creams, and suppositories are used to treat certain types of erectile dysfunction in men. Alprostadil injection is also sometimes used in conjunction with other tests to diagnose erectile dysfunction. Alprostadil is a medication that belongs to a class of drugs known as vasodilators. In order for an erection to occur, it must first relax the muscles and vessels of the penis, allowing enough blood to remain in the penis to allow for this to happen.

Why Is Alprostadil Prescribed?

Alprostadil has been found to be effective for men with erectile dysfunction who do not respond well to other treatments. 

It’s been found that more than 80 percent of men with erectile dysfunction, regardless of their age or the cause of their ED, can get an erection firm enough for sex after taking the injectable form of this medication. 

The suppository form is less effective than the oral form, but it does produce an erection in approximately 30 percent to 40 percent of men with ED.

Alprostadil usually begins to work within 5 to 20 minutes of being turned on. Wait 10 to 30 minutes before having sexual relations. If everything goes according to plan, your erection should last about an hour and may even last longer. 

It should not be used more than three times per week. Each use should be separated by at least 24 hours.

Who Should Avoid Taking Alprostadil?

Who should avoid Alprostadil

This drug has some risks. Before you take it, consult with your doctor.

If you have ever had an allergic reaction to alprostadil or are taking other medication for the heart, you should avoid taking the drug until you’ve been given the go signal from your doctor.

Alprostadil Side Effects

If you feel symptoms of a severe allergic reaction, including hives, difficulty breathing, swelling of your face, lips, tongue, or throat, stop using alprostadil immediately and call your doctor. Your doctor may want to test you for a serious condition called systemic anaphylaxis.

A painful erection, new or worsening pain in your penis, redness, swelling, tenderness, lumps, or an unusual shape or curving of your erect penis are all possible side effects of Alpostradil.

Common side effects may include a mild burning in your urethra or penis, or tenderness in the area of the urethra and testicles. Your partner may also have symptoms such as burning, itching, or irritation of the body parts that come into contact with your penis.

Before Taking Alprostadil

Tell your doctor and pharmacist if you are allergic to alprostadil.

Tell your doctor and pharmacist about all the medications, vitamins, nutritional supplements, and herbal products you are taking or planning to take.

It is also important to find out if you or your family has a genetic disorder that puts them at risk for thrombosis (a blood clot) and to get the right medicine if they do.

You need to be aware that a small amount of bleeding may occur in the area where the medication was administered. Blood-borne diseases (diseases that are spread through contaminated blood) such as HIV, hepatitis B, and hepatitis C can be transmitted more easily between you and your partner due to this relationship. Inform your doctor if you or your partner has been exposed to a blood-borne illness.

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How To Inject Alprostadil

How to inject Alprostadil

Your doctor will instruct you on how to administer the injection to yourself. You can prepare the mixture you’ll inject if you want to, just follow the directions provided. 

Use soap and water to thoroughly clean your hands before drawing the medication into the syringe. Place the bottles on a clean surface and set them aside. An alcohol swab should be used to clean the tops of the injection bottles. 

It is imperative that you use a single dose as soon as possible after mixing it. Any remaining mixture in the syringe should be discarded. Don’t keep it because you won’t be able to use it later. 

Remove the needles from the room. Please do not re-use them! 

You should consult your doctor or pharmacist if you have any questions about how to use this medication.

How To Insert Alprostadil Suppository

First and foremost, urinate. In addition, the small amount of urine remaining in the urethra will aid in the dissolution of the suppository. 

The suppository is about the size of a grain of rice, and it has a rounded shape. The applicator will be used to insert the device into the urethra (the opening at the end of the penis), which is a plastic tube. 

It is possible to use a small amount of lubricant, such as KY Jelly or Astroglide, to assist you with inserting the applicator. To deliver the suppository into the urethra, press the button on the applicator to the right. 

Rolling your penis between your hands for 10 seconds will aid in dissolving the suppository once it has been placed inside. If you experience any stinging, keep moving in this direction to help the sensation subside. 

Sit, stand, or walk for around 5 to 10 minutes to increase blood flow to your penis, which will aid in obtaining an erection. 

Alprostadil Injection Vs Suppository

The decision between an injection and a suppository is a matter of personal preference. Consult with your doctor about the advantages and disadvantages of the procedure. For example, while an injection may be more painful, it is more effective than a suppository in treating the condition. Another thing is that the suppository form of Alprostadil doesn’t work for everyone, while the injection has a higher success rate in producing an erection. 

What About Alprostadil Creams?

What about Alprostadil creams

Alprostadil cream is a topical application of the drug alprostadil that is used to treat erectile dysfunction in patients. 

Alprostadil is a prostaglandin that occurs naturally in the body and is used to improve blood flow by dilation of blood vessels. 

When alprostadil is applied topically to the penis in the form of a topical cream, it makes it easier to achieve and maintain an erection. 

Topical alprostadil cream has the potential to be an important second-line treatment for erectile dysfunction. It is less invasive than other second-line treatment options, it has fewer side effects, and it is simple and painless to use. It is also effective. 

A growing body of evidence supports the theory that topical alprostadil cream is a safe and effective alternative to conventional erectile dysfunction treatments. 

Now, here’s the catch: at this time, Vitaros topical cream has not been approved by the FDA for the treatment of erectile dysfunction, and it is only available by prescription in the United Kingdom and a few other countries.

Advantages of Alprostadil Cream

It is a good option for men with ED who are unable to take first-line ED treatments, such as oral PDE5 inhibitors due to drug interactions. Alprostadil cream is a prescription medication that is available over the counter. 

Compared to Alprostadil cream, oral medications such as Viagra and Cialis cannot be taken in conjunction with nitrates, and they should be used with caution and under the strict supervision of your healthcare providers when combined with alpha-blockers and amlodipine. 

Because alprostadil cream has no interactions with food or alcohol, it has the additional benefit of allowing for greater sexual spontaneity during a sexual encounter.

If there is any disadvantage to Alprostadil creams, it’s that they only work for 40% of men who try them. For these men, they’ll need to go for either the injection or the suppository, or a different ED drug altogether.


The treatment of erectile dysfunction is not a simple process. You may experience side effects. It is important to inform your doctor if you experience any side effects. 

Alprostadil Injection and Suppository are not approved for use by everyone. They are only for use in treating erectile dysfunction.

Ask your doctor if you have any questions about the treatment of erectile dysfunction.

All medications have risks and benefits. Your doctor will discuss the benefits and risks of Alprostadil Injection and Suppository with you. 

Remember that Alprostadil Injection and Suppository should not be used to treat all cases of erectile dysfunction. Consult your doctor if you have any concerns or questions about the treatment of erectile dysfunction.

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